Melatonin's Real Effects on Sleep: What 34 Clinical Trials Reveal About Dosage, Timing, and Who It Actually Helps
Over 27% of Americans take melatonin, but research shows it reduces sleep onset by just 7-11 minutes for general insomnia.
86 articles
Over 27% of Americans take melatonin, but research shows it reduces sleep onset by just 7-11 minutes for general insomnia.
Ponatinib, a drug approved for leukemia, unexpectedly boosts immune cells that fight cancer by preventing exhaustion in CAR T cell therapy, offering a new...
Histotripsy, a breakthrough non-invasive ultrasound technology, is destroying kidney tumors without surgery, heat, or radiation.
A major analysis of 80 randomized trials involving nearly 10,000 people with knee osteoarthritis found acupuncture reduced pain by about 40%, rivaling some...
Autologous platelet concentrates may accelerate healing in tendon and ligament injuries, but inconsistent protocols and lack of standardization limit their...
A troubling trend reveals patients are abandoning medications backed by 170,000-person studies for experimental peptides tested on just 14 humans.
New meta-analyses reveal machine learning models can accurately predict stroke mortality and lung cancer recurrence, but methodological gaps and lack of...
HyBryte, a novel photodynamic therapy using visible light, showed 60% treatment success versus 20% for standard chemotherapy in cutaneous T-cell lymphoma, with...
Modafinil shows promise for adult ADHD symptoms like focus and cognitive fatigue, but research is mixed and FDA approval remains unlikely due to rare serious...
A real-world clinical trial found that TENS therapy combined with physical therapy significantly reduces both pain and fatigue in fibromyalgia patients, with...
A study of 485 nurses shows strong support for IVF and egg freezing, but resistance to donation and surrogacy.
The NIH is implementing major changes to its grants process in 2026, including new data-sharing requirements, clinical trial definitions, and approval...
The FDA is removing black box warnings from hormone replacement therapy products for menopause, citing research showing improved health outcomes.
Minneapolis Heart Institute researchers are showcasing 45 cardiovascular studies at the 2026 American College of Cardiology conference, including 3...
A major review of 535 clinical trials found robot-assisted therapy significantly improves arm strength after stroke, but benefits don't always translate to...
Researchers discovered bacteria living inside kidney stones, challenging how doctors understand stone formation.
The NIH is overhauling how researchers handle patient data, proposing stricter controls for human subject information while reducing duplicative policies.
The NIH redefined clinical trials to exclude basic human research studies, eliminating registration requirements.
A clinical trial published in The Lancet Respiratory Medicine shows Polymyxin B hemoadsorption reduces 90-day mortality by 15.5% in endotoxic septic shock...
A new peer-reviewed study validates a functional vision test that captures real-world improvements in severe vision loss, offering doctors a better way to...
Wearable technologies are transforming clinical trials by enabling continuous monitoring of drug effects, with adhesive patches now dominating deployments...
Esketamine nasal spray (Spravato) offers FDA-approved hope for treatment-resistant depression when standard antidepressants fail.
Artificial intelligence is accelerating pharmaceutical drug discovery by years, yet a critical bottleneck persists: experimental validation can't keep pace...
Wearables and sensors are reshaping clinical research by continuously tracking health metrics, but major barriers prevent most digital biomarkers from reaching...
Researchers discovered that thymic health, measured on routine CT scans, predicts immunotherapy success better than traditional tumor markers.
Researchers found that type 2 diabetes, heart disease, and cancer all exploit the same oxygen-starved cellular pathway.
A randomized controlled trial of 300 Japanese workers found that a self-guided meditation app improved work performance, but between-group differences were...
NIH grants $2 million to develop DARE-PTB1, a novel intravaginal ring delivering progesterone to prevent preterm birth, a condition with no current...
A new NIH-led review settles a decades-old medical debate: topical steroid withdrawal is a distinct condition, not just underlying skin disease.
Researchers have identified specific genetic markers that predict scoliosis risk, while advanced imaging technologies enable earlier detection and less...
Researchers tested an mRNA vaccine against deadly Nipah virus in 40 healthy adults.
A major analysis of 13 clinical trials reveals digital health tools significantly improve hip function and mobility in older adults recovering from hip...
New research compares three brain stimulation methods for treatment-resistant auditory hallucinations affecting 60-80% of schizophrenia patients.
New research shows cardiac arrest survivors struggle with memory loss, fatigue, and depression long after recovery.
Researchers fine-tuned artificial intelligence to detect what smokers really need in support group messages, improving accuracy from 38% to 90%—potentially...
Randomized controlled trials and meta-analyses are the gold standard for medical research. Here's how scientists cut through the noise to find real answers.
The FDA approved 46 new drugs in 2025, marking a slight slowdown but revealing major shifts in cancer treatment and biologics.
A major new blueprint reveals how fragmented health records are slowing medical breakthroughs.
The FDA is increasingly rejecting clinical trials for cancer drugs when they lack sufficient U.S.
The FDA is reviewing five potentially game-changing medications in January 2026, including the first oral epinephrine for anaphylaxis and new treatments for...
The NIH is training researchers to embed clinical trials directly into hospitals and clinics, generating real-world evidence that could transform how doctors...
A new systematic review found that GLP-1 receptor agonists may reduce breast cancer-related lymphedema risk, while immunomodulatory therapies showed promise...
GM1 gangliosidosis, a rare genetic disorder, is moving toward its first AAV gene therapy clinical trial in 2026.
A nonprofit organization is applying rigorous clinical trial methods to study consciousness, publishing over 670 peer-reviewed studies—but experts caution...
The NIH RECOVER initiative is launching the first large-scale clinical trials for Long COVID, testing four treatment strategies including a JAK inhibitor and...
University at Buffalo's health sciences schools secured over $65 million in NIH funding, ranking among the nation's top research institutions.
The National Institute on Deafness and Other Communication Disorders is launching three major data platforms to accelerate hearing loss research.
The NIH unified funding strategy eliminates paylines and standardizes grant decisions across 12 institutes.
A groundbreaking collaboration between the VA and NIH is launching Project IN-DEPTH to understand why up to one-third of 700,000 Gulf War veterans remain sick...
A vagus nerve implant safely reduced joint damage in rheumatoid arthritis patients who failed medication.